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NET, A TRANSCRIPTION FACTOR OF THE TCF FAMILY, AS REGULATOR OF ANGIOGENIC FACTOR EXPRESSION

机译:NET,TCF家族的转录因子,作为血管生成因子表达的调节因子

摘要

The present invention relates to the regulation of the activity of NET(ERP/SAP-2) protein and to compounds which modify or regulate NET proteinactivity. The invention further relates to methods of screening for agonistsor antagonists of NET in order to identify new pro-angiogenic or anti-angiogenic compounds and to therapeutic uses of these compounds. The inventionalso relates to transgenic animals bearing mutations in NET gene.
机译:本发明涉及NET活动的调节(ERP / SAP-2)蛋白以及修饰或调节NET蛋白的化合物活动。本发明进一步涉及筛选激动剂的方法。或NET拮抗剂以鉴定新的促血管生成或抗血管生成药物血管生成化合物以及这些化合物的治疗用途。本发明还涉及带有NET基因突变的转基因动物。

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