食欲素A与慢性阻塞性肺疾病患者呼吸中枢驱动的相关性研究

摘要

Obejective To explore the correlation of Orexin A and respiratory drive in chronic obstructive pulmo-nary disease (COPD) patients. Methods Pulmonary function was tested in 30 stable COPD patients and 20 normal healthy adults. Plasma orexin A level was measured with a radioimmunoassay kit. The correlation of Orexin A with BMI, age, BDI, FEV1, FVC, FEV1/FVC, MEP, MIP, P0.1 in COPD patients was analyzed. Results Plasma Orexin A levels in patients with COPD group(1.87±0.43)ng/L was higher than those in the control group(1.49±0.19)ng/L, P<0.01. Plasma Orexin A lev-els in patients with COPD correlated negatively with FEV1(r=-0.389,P < 0.05),and correlated positively with P0.1(r=0.728,P<0.01). Conclusion Plasma orexin A in COPD patients increased which may be caused by smoking and hyper-capnia. Orexin A may play a crucial role in regulating respiratory drive in COPD patients.%目的：探讨食欲素A水平与慢性阻塞性肺疾病（COPD）患者呼吸中枢驱动之间的关系。方法收集30例稳定期COPD患者为COPD组，以20例健康体检者为健康对照组。记录所有受试者体质指数（BMI）、年龄、COPD组患者吸烟史。测定血浆食欲素A水平，并于采血当天上午测定肺功能，包括第1秒用力呼气容积（FEV1）、用力肺活量（FVC）和FEV1/FVC、最大呼气压（MEP）、最大吸气压（MIP）、口腔闭合压（P0.1）。结果 COPD组患者血浆食欲素A水平（1.87±0.43）ng/L高于健康对照组（1.49±0.19）ng/L（t=3.665，P<0.01）。COPD组患者血浆食欲素A与FEV1呈负相关（r=-0.389，P<0.05），与P0.1呈正相关（r=0.728，P<0.01），与年龄、BMI、MEP、MIP均无相关性（均P>0.05）。结论 COPD患者血浆食欲素A水平升高，其原因可能与吸烟和高碳酸血症有关，且食欲素A可能参与COPD呼吸中枢驱动的调节。