聚丙烯酸水凝胶的制备及其对结晶紫的控制释放

摘要

Polypropylene acid hydrogels was prepared by free radical polymerization. The effect of cross-linking agent, the monomer and salt on swelling properties of the hydrogel was studied. Crystal violet was used as a template to study the properties of hydrogel controlled release crystal violet. The results showed:with 0.8%crosslinking agent and 70%neutralization of monomer, hydrogel had the best swelling performance. Under the same conditions, polypropylene acid hydrogels swelling ratio decreased with the increase of the salt solution concentration. Polypropylene acid hydrogels had a good performance for drug controlled release, and the release of crystal violet was diffusion mechanism.%通过自由基聚合制备出聚丙烯酸水凝胶，考察了交联剂、单体中和度、盐对水凝胶溶胀性能的影响，以结晶紫为模板研究了水凝胶对结晶紫的控制释放性能。结果表明，交联剂用量在0.8%，单体中和度为70%时水凝胶溶胀性能最佳；在相同条件下，聚丙烯酸水凝胶的溶胀率随盐溶液浓度的增大而降低；聚丙烯酸水凝胶对药物具有良好的控制释放性能，对结晶紫的释放为扩散机制。