异常凝血酶原联合唾液酸在慢性肾功能不全患者诊断中的价值分析

摘要

Objective To investigate the diagnosis value of abnormal thrombin original combined with sialic acid for chronic renal insufficiency. Methods 68 cases with chronic renal insufficiency from August 2013 to September 2015 in our hospital were detceted with abnormal prothrombin and sialic acid,then calculated abnormal prothrombin, sialic acid alone and sensitivity, specificity, positive predictive value and negative predictive value with chronic renal insufficiency were compared. Results The abnormal prothrombin was (23.5±2.1)mAU/mI,and sialic acid levels was (86.5±2.9)mg/dL, they were higher than normal reference range(P<0.05),the sensitivity(87.3%), specificity(98.3%), positive predictive value (95.1%)and negative predictive value (79.8%)of combined detection were higher than abnormal prothrombin and sialic acid determination alone. Conclusion The abnormal prothrombin and sialic acid detection can improve the effi-ciency of diagnosis with chronic renal insufficiency.%目的：探讨异常凝血酶原联合唾液酸在慢性肾功能不全患者诊断中的价值。方法选择2013年8月—2015年9月该院收治的慢性肾功能不全患者68例,分别进行异常凝血酶原与唾液酸检测,计算异常凝血酶原、唾液酸单独与联合检测对诊断慢性肾功能不全的敏感性、特异性、阳性预测值及阴性预测值。结果患者异常凝血酶原为(23.5±2.1)mAU/mL,唾液酸为(86.5±2.9)mg/dL,均高于正常参考范围(P<0.05),联合检测敏感性(87.3%)、特异性(98.3%)、阳性预测值(95.1%)及阴性预测值(79.8%)均高于异常凝血酶原和唾液酸单独测定(P<0.05)。结论异常凝血酶原和唾液酸联合检测,可显著提高慢性肾功能不全的诊断效率。