丹参酮ⅡA磺酸钠对大剂量电离辐射小鼠生存率的影响

摘要

Objective To investigate the effects of tanshinone ⅡA sulfonate on the survival of mice exposed to high dose of irradiation. Methods Mice were exposed to 11 Gy irradiation and divided into the saline control group, the 50 mg/kg, 75 mg/kg and 100 mg/kg group. Saline or tanshinone ⅡA sulfonate was given by intraperitoneal injection before and after irradiation. Results The mice stopped growth after irradiation. Body weight was higher in the groups of 75 mg/kg and 100 mg/kg than that in the control group and the 50 mg/kg group. Mean survival day was (9.5 ± 1.5)d, (10. 1±1.1)d, (10.5±1.2)d and (11.5 ± 1.0) d in the four groups. The analysis of survival curve showed cum survival was significantly higher in the group of 100 mg/kg than that in the control group and the 50 mg/kg group (all P < 0.01). Conclusion 100 mg/kg sodium tanshinone ⅡA sulfonate improves the quality of life and survival days of mice exposed to high dose of irradiation.%目的:探讨丹参酮ⅡA磺酸钠(STS)对大剂量电离辐射小鼠生存率的影响.方法 小鼠一次性接受11Gy的60Co照射,分为生理盐水对照组和50 mg/kg、75 mg/kg和100 mg/kg3个STS剂量组,于照射前1h和照射后0.5h和24h腹腔注射生理盐水或STS.结果 照射后小鼠停止生长,照射后第7天75 mg/kg组小鼠体质量(20.3±2.2 g)显著高于对照组(17.6±1.8 g)(P ＜0.05).小鼠的存活天数随STS注射剂量的增加依次为(9.5±1.5)d、(10.1±1.1)d、(10.5±1.2)d和(11.5±1.0)d.生存曲线分析显示,100 mg/kg组小鼠的生存率显著高于对照组和50 mg/kg组(均P＜0.01).结论100 mg/kg STS注射后明显提高了大剂量电离辐射暴露后小鼠的生存质量和生存率.