银杏达莫联合奥扎格雷钠治疗急性脑梗死临床研究

摘要

目的 探讨银杏达莫注射液联合奥扎格雷钠注射液治疗急性脑梗死(Acutecerebralinfarction,ACI)临床疗效.方法 156例ACI患者按就诊顺序1:1比例随机分为治疗组和对照组,各78例. 两组患者均给予常规综合治疗,治疗组加用银杏达莫注射液20 mL稀释后静脉滴注,奥扎格雷钠氯化钠注射液80mg(100mL)静脉滴注,均1日1次;对照组加用复方丹参20mL稀释后静脉滴注,胞二磷胆碱1.0稀释后静脉滴注,均1日1次.两组疗程均为10d.结果 ①治疗组总有效率为92.3%(72/78),对照组总有效率为80.8%(63/78),治疗组治疗效果明显优于对照组(P<0.05);②治疗后治疗组DNDS改善明显优于对照组(P<0.01);③治疗组治疗后 DNDS明显低于治疗前(P<0.01). 结论 银杏达莫注射液联合奥扎格雷钠注射液治疗ACI具有疗效确切、安全可靠、副作用少等优点,值得临床推广使用.%OBJECTIVE To evaluate the clinical efficacy of Yinxingdamo injection combined with ozagrel sodi-uminjectioninthetreatmentofacutecerebralinfarction(ACI).METHODS 156casesofACIpatientsaccording to the order of the ratio of 1:1 were randomly divided into treatment group and control group,78 cases in each.Two groups of patients were given conventional therapy,the treatment group were further treated with ginkgo leaf extract and dipyridamole injection 20mL diluted intravenous drip, 80mg ozagrel sodium and sodium chloride injection (100mL) intravenous injection,1 times daily;the control group were further treated with Compound Danshen 20mL diluted intravenous drip, citicoline 1.0 diluted intravenous drip, 1 times daily.Two groups were treated for 10d.RESULTS ①Thetreatmentgrouptotaleffectiveratewas92.3%(72/78)thecontrolgrouptotaleffectiverate was 80.8%(63/78),treatment group was better than the control group (P<0.05);②After treatment,DNDS of treatment group improved significantly better than the control group ( P<0.01);③After treatment,DNDS was signif-icantly lower than that before treatment ( P<0.01 ) .CONCLUSION Ginkgo leaf extract and dipyridamole injec-tion combined with ozagrel sodium injection in the treatment of acute cerebral infarction has the advantages of exact curative effect,safety and side effects less,which is worthy of clinical use.