A new method is presented for synthesizing δ-decalactone from n-valeraldehyde and cyclo-pentanone via the reaction process of aldol condensation, selective catalytic hydrogenation and oxidation. The optimum process conditions acquired through the orthogonal experiments were as follows:w(NaOH) = 1%, m(PEG-600)=0. 7 g, m(oxalic acid) =0.2 g, n(hydrogen peroxide) :n(2-amyl cyclopentanone) = 4:1, V(methanol) = 30 mL, V(sulfuric acid) = 2 mL, and the final yield was 61. 2% , which is superior to the literature reported value of 52%. The intermediates and product were characterized by IR and GC-MS. To compare with the traditional methods, the raw materials are easy available, the reaction route is simple, the product yield is relatively high and the operation is quiet safe via this method.%以环戊酮和正戊醛为起始原料,经羟醛缩合、选择性催化加氢、氧化重排制得δ-癸内酯.通过正交实验,得出最佳工艺条件:w(NaOH)=1％,PEG-600用量0.7g,草酸用量0.2g,n(双氧水)∶n(2-戊基环戊酮)=4∶1,甲醇用量30 mL,硫酸用量2 mL,反应收率为61.2％.采用红外光谱对产物结构进行了表征.
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