中药作用靶点的预测及发现方法研究进展

摘要

Compared to the drug with single target ,traditional Chinese medicines (TCM ) with the overall therapeutic effect have the typical mechanism such as multi-components ,multi-targets and multi-channels.In this system ,many compounds together produce a synergistic ef-fect on the purpose of reducing toxicity and improving the therapeutic effect.It is really important for TCM that the molecular mechanism will be clarified and be confirmed.The confirmed targets would provide an important reference for the clinical application of TCM.According to the re-cently studies ,the prediction ,identification and validation of the multi -target that TCM acted on are mainly through network pharmacology , computer-aided drug design ,pr-oteomics and bioship.By reviewing the literature in five years ,this paper would provide a good reference for the methods applying in mechanism studying of TCM.%与单一作用靶点的药物相比较 ,中药的作用机制为典型的多成分、多靶点、多途径的整体性治疗 ,各药物之间能够产生协同作用 ,最终达到增效减毒的目的.确证中药作用的靶点 ,对阐明我国传统药物的作用机制具有重要的理论价值 ,也为中药的临床应用提供重要参考.近年来研究表明 ,对中药多组分作用多靶点的探究主要是通过网络药理学、计算机辅助药物设计、蛋白质组学、生物芯片等途径实现.本文综述了近5年在中药作用靶点预测、识别和确证研究中所采用的主要方法和途径 ,为进一步阐明中药的作用靶点提供了参考.