cathepsin B和cystatin C在人脑胶质瘤中的表达及意义

摘要

To explore the expression and significance of cystatin C and cathepsin B in human gliomas. Methods A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples. Results The expression of cystatin C in high-grade (Grade Ⅲ-Ⅳ) gliomas was significantly weaker than that in low-grade(Grade Ⅰ-Ⅱ). On the other hand, the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade (P < 0.05 ). Cystatin C expression correlated inversely with cathepsin B expression in gliomas (P = 0.01). Conclusion Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas. Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas.%目的 探讨半胱蛋白酶抑制剂C(cystatin C)和组织蛋白酶B(cathepsin B)在人脑胶质瘤组织中的表达及意义.方法 通过免疫组织化学法检测cystatin C及cathepsin B在57例不同分化程度的脑胶质瘤组织中的表达.结果 cystatin C在低分化胶质瘤( Ⅲ-Ⅳ级)中的表达低于高分化者(Ⅰ～Ⅱ级),而cathepsin B在低分化胶质瘤中的表达高于高分化者(P＜0.05).cystatin C和cathepsin B在脑胶质瘤中的表达呈负相关(P=0.01).结论 cystatin C和cathepsin B的表达与人脑胶质瘤病理分级及侵袭性相关.联合检测cystatin C和cathepsin B的表达,可为脑胶质瘤的侵袭性及临床恶性程度评估提供重要信息.