SLP-2和 IGF-1R 在胃癌组织中的表达及意义

摘要

Objective To study the expressions of SLP-2 and IGF-1R in gastric cancer and the correlation with its biolog-ical behavior. Methods The expressions of SLP-2 and IGF-1R protein was detected by immunohistochemistry in 50 cases of hu-man gastric adenocarcinoma and adjacent tumor-free tissue respectively. Results ①High expressions of SLP-2 and IGF-1R pro-tein were observed in 66% (33 / 50) and 70% (35 / 50) of gastric cancer tissues respectively,significantlyhigher than those in non-tumor renal tussues 20% and 48% (P < 0. 05). ②The expression of SLP-2 in gastric cancer tissues correlates with the metas-tasis of lymph nodes and diffential grade(P < 0. 05),but were not significantly related to the sex of patients or the age of patients. The expression of IGF-1R in gastric cancer tissues correlates with the metastasis of lymph nodes(P < 0. 05),but were not signifi-cantly related to the diffential grade or the sex of patients or the age of patients. Conclusion The abnormal expressions of SLP-2 and IGF-1R protein are significantly correlated with the creation,the development and the metastasis of gastric cancer.%目的：探讨 SLP-2和 IGF-1R 在胃癌中的表达及其与生物学行为的关系。方法选取我院病理科有完整临床资料的胃癌组织标本50例，应用免疫组织化学(SP 法)方法检测 SLP-2和 IGF-1R 在胃癌及正常胃粘膜中的表达。结果①胃癌组织中 SLP -2高表达率为66%；在其癌旁正常胃粘膜中高表达率为20%；IGF-1R 在胃癌中的高表达率为70%，在正常胃组织中的高表达率为48%，两者间的差异均有统计学意义(P <0．05)。②SLP-2在胃癌中的表达与淋巴结转移及分化程度有关(P <0．05)，与性别、年龄无关；IGF-1R 在胃癌中的表达与淋巴结转移有关(P <0．05)，与性别、年龄及分化程度无关。结论 SLP-2和 IGF-1R 的异常表达可能与胃癌的发生发展密切相关，两者在胃癌的恶性进程中起重要作用。