C-反应蛋白和 D-二聚体在下肢深静脉血栓形成中的临床意义

摘要

目的：研究炎症因子血清C-反应蛋白（CRP）、D-二聚体（DD）在下肢深静脉血栓形成（DVT ）急性期的临床意义。方法检测49例DVT急性期住院患者治疗前、治疗3 d及治疗7 d后血清CRP、DD浓度，与28名健康对照组作对比研究。结果病例组血清CRP、DD浓度均高于对照组（P＜0.01），治疗3 d后CRP开始下降，且CRP、DD与治疗前比较差异有统计学意义（P＜0.01），病例组治疗7 d后CRP较治疗前明显降低，差异有统计学意义（P＜0．01），DD降低到治疗前水平。结论联合动态监测血清CRP和DD在DVT急性期患者的病情演进过程中具有一定的临床指导价值。%Objective To investigate the clinical value of C reactive protein (CRP)and plasma D-Dimer(DD) in patients with lower limb deep venous thrombosis (DVT ) of acute phase .Methods Twenty-eight healthy indi-viduals (control group) and 49 patients with acute phase of DVT (experimental group) were enrolled .Serum con-centration of CRP and DD were detected for experimental group before treatment and 3 and 7 days after treatment . And those examination results were compared with those of 28 cases in normal control group results .Results There were statistical differences of serum concentration of CRP and DD between the results of experiment group and control group before and after treatment ( P<0 .01) .Serum concentration of CRP started to decrease 3 days after treatment ,and there were significant differences compared with the concentration of CRP and DD before treatment ( P<0 .01) .Seven days after treatment ,the concentration of CRP was significantly lower than those before treatment ( P<0 .01) .The concentration of DD decreased to the levels before treatment .Conclusion CRP and DD seem to be significant indicators for diagnosis and evaluating curative effect for DVT of acute phase.