C-反应蛋白、白介素-6和D-二聚体在下肢深静脉血栓形成患者干预前后血清中的表达及意义

摘要

Objective To analyse the variation of C-reactive Protein,Interleukin-6 and D-Dimer in the Pre-therapy and Post-treatment Period of the DVT,to explore the significance of the three indexes.Methods 30 patients documen-ted with acute phase of lower limb DVT(DVT group)and 30 healthy individuals(normal control group)were included in this study,The plasma level of CRP,IL-6 and D-Dimer in both groups and the difference of perimeters between the lower limbs before and 3,7 days after the treatment in DVT group were recorded.Results The plasma level of CRP, IL-6 and DD of DVT group before the treatment were statistically higher than those of normal control group (P<0.05).The plasma level of CRP,IL-6 and the difference of perimeters between the lower limbs statistically reduced af-ter the treatment.The plasma level of CRP and IL-6 decreased vitally than before after the treatment 3,7 days(P<0.05),but the level of DD increased than before after the treatment 3 days(P<0.05),then it began to reduced also.Af-ter the treatment 7 days,the level of the three indexes were all statistically lower than the treatment 3 days(P<0.05). Conclusion Inflammatory factors possibly play an important role in acute phase of DVT.There was a crucial clinical value to combine detect the CRP,IL-6 and DD levels of serum in patients with acute DVT in its early diagnosis,occur-rence,development and prognosis.%目的：探讨C-反应蛋白（CRP）、白介素-6（IL-6）和 D-二聚体（DD）在下肢深静脉血栓形成（DVT）患者治疗前后血清中的表达及意义。方法选取 DVT患者30例为 DVT组，我院体检的健康人30例为正常对照组。检测DVT组患者治疗前后及正常对照组血清CRP、IL-6及DD的浓度，测量 DVT组患者治疗前后健、患肢周径差。结果治疗前DVT组CRP，IL-6和DD的血清浓度均显著高于正常对照组（P＜0．05）。随着治疗时间的延长，CRP，IL-6的浓度逐渐降低，患、健肢体周径差显著减少。治疗3 d后，CRP 和 IL-6的浓度与治疗前相比显著降低（P＜0．05）。而DD的浓度与治疗前相比显著升高（P＜0．05）。治疗7 d后与治疗3 d相比，CRP和 IL-6的浓度进一步降低，DD的浓度也出现下降趋势，差异均有统计学意义（P＜0．05）。结论急性炎性反应因子可能在下肢 DVT的形成中起重要作用，联合动态监测CRP，IL-6和DD的浓度对于DVT的诊断、病程进展和预后判断有重要的临床实用价值。