目的：探讨青年急性缺血性卒中的危险因素。方法回顾性分析2013年1月至2015年1月于中国医科大学附属第四医院神经内科住院治疗的77例青年急性缺血性卒中患者（青年卒中组）的临床资料，随机抽取同期住院的中年急性缺血性卒中患者81例作为对照组，对危险因素进行单因素及多因素分析。结果77例青年卒中患者中男性61例（79.2％），其美国国立卫生研究院卒中量表（NHISS）评分显著高于女性患者（t＝－2.267，P＝0.026）；有吸烟史57例（74％），与对照组差异有统计学意义（χ2＝5.168，P＝0.023）；同型半胱氨酸水平较对照组高（ t＝－3.998，P＝0.000）；而对照组高血压病史（χ2＝8.113，P＝0.004）及糖尿病病史（χ2＝7.788，P＝0.005）较青年组高，且NHISS评分高于青年组（t＝2.589，P＝0.011）。结论青年卒中患者中男性居多，且男性患者的神经功能缺损症状严重于女性；吸烟史及高同型半胱氨酸可能是导致青年急性缺血性卒中的重要危险因素。%Objective To explore the risk factors of acute ischemic stroke in young adults .Methods We retrospectively analyzed clinical data of 77 acute ischemic stroke patients (Young group) who were treated in the Department of Neurology of the Fourth Affiliated Hospital of China Medical University from January 2013 to Jan‐uary 2015 .And 81 cases in the middle‐aged patients with acute ischemic stroke were randomly enrolled as the con‐trol group .Risk factors were analyzed by univariate and multivariate analysis .Results In 77 young stroke pa‐tients ,61 cases (79.2% ) are male ,and the NHISS score is significantly higher than female patients (t= -2.267 , P=0.026) .Fifty‐seven cases (74% ) have smoking history ,there is significant difference compared with the con‐trol group (χ2 = 5.168 , P= 0.023) .The higher homocysteine level is the control group (t= -3.998 , P=0.000) .And the control group with hypertension (χ2 = 8.113 , P= 0.004) and the history of diabetes (χ2 =7.788 ,P=0.005) compared with young group is higher ,and NHISS score is also higher (t=2.589 ,P=2.589) . Conclusion Young stroke patients are mostly male ,and the neural function defect symptoms of male patients is more serious than those of women .Smoking and homocysteine probably are the important risk factors for acute is‐chemic stroke in the young .
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