莪术对人宫颈癌Hela细胞增殖及免疫功能的影响

摘要

目的：探讨莪术对人宫颈癌细胞的增殖及免疫功能的影响。方法将50只裸鼠移植瘤模型简单随机分成5组，分别给予不同的处理，观察小鼠的免疫功能及癌组织的病理结果变化；用 M TT 方法检测莪术水煎液对宫颈癌 Hela 细胞的抑制作用。结果莪术抑制宫颈癌细胞的生长，最高达（71．2±3．4）％，呈时间、浓度依赖性；不同剂量莪术组与顺铂组相比较，莪术对小鼠免疫功能影响不大，白细胞降低不明显，差异有统计学意义；病理切片可见莪术治疗组的癌组织可出现不同程度的坏死。结论莪术抑制宫颈癌细胞的生长，促进癌细胞凋亡，对机体的不良反应小，较安全。%Objective Effect of Rhizoma Curcumae proliferation and immune function of cervical cancer cell . Methods The model of transplanted tumor of 50 mice were randomly divided into 5 groups ,were given different treatment ,pathological results observation of immune function of mice and cancer tissue changes ;inhibitory effect on Hela cells of cervical cancer by M T T method for detection of zedoary Decoction• Results Rhizoma Curcumae inhibit the growth of cervical cancer cells ,up to (71 .2 ± 3 .4)% ,which shows the dependent of time and concen‐tration ;Compare cisplatin group with different doses of Rhizoma Curcumae group ,little effect of Rhizoma Cur‐cumae on immune function in mice ,the decrease of white blood cell is not obvious ,the difference is statistically significant ;pathological section shows cancer tissue of Rhizoma Curcuma treatment group can appear different de‐gree of necrosis .Conclusion Conclusion Rhizoma Curcumae inhibit the growth of cervical cancer cells ,and pro‐mote apoptosis of cancer cells ,small side effects on the body ,relatively safe.