幽门螺杆菌感染与胃炎不同部位及病理学特征的关系研究

摘要

目的 探讨幽门螺杆菌(Hp)感染与不同胃炎类型及病理学的关系研究.方法 选取在本院消化内科就诊的胃炎患者153例,比较不同类型胃炎患者Hp感染率的差异;比较不同病理参数间Hp感染率的差异.结果 慢性萎缩性胃炎患者HP阳性3例,阳性率为16.7%;慢性非萎缩性胃炎患者HP阳性33例,阳性率为50.8%;慢性萎缩性胃窦炎患者Hp阳性2例,阳性率为7.1%;慢性非萎缩性胃窦炎患者Hp阳性15例,阳性率为35.7%;不同类型胃炎患者Hp感染率的差异具有统计学意义(P<0.05).胃炎患者炎症反应重度者的Hp感染率(85.7%)高于中度炎症反应者(39.7%)和轻度炎症反应者(16.2%);重度中性粒细胞浸润者的Hp感染率(73.7%)高于轻度者(29.1%);重度淋巴细胞浸润者的Hp感染率(50.0%)高于轻度者(29.9%);有肠上皮化生者的Hp感染率(66.7%)高于无肠上皮化生者(26.8%);上皮内瘤变者的Hp感染率(83.3%)高于无上皮内瘤变者(30.5%),且差异均有统计学意义(P<0.05);结论 不同类型的胃炎患者Hp感染率差异有统计学意义,Hp感染率随炎症程度的加重而升高,且Hp感染可能促进了肠上皮化生和上皮内瘤变的发展.%Objective To investigate the relationship between Hp infection and different gastritis types and pathology.Methods One hundred and fifty three cases of gastritis patients in digestive department of our hospital were selected,Hp infection rates were compared among patients with different types of gastritis.The difference of Hp infection rate between different pathological parameters was compared.Results In chronic atrophic gastric si-nusitis,3 cases were Hp positive,the positive rate was 16.7%;In chronic non-atrophic gastritis patients,33 ca-ses were Hp positive,the positive rate was 50.8%.In chronic atrophic antral gastritis,Hp was positive in 2 ca-ses,and the positive rate was 7.1%;In chronic non-atrophic antral gastritis,Hp was positive in 15 cases,and the positive rate was 35.7%;The difference of Hp infection rate among different types of gastritis patients was statis-tically significant (P <0.05).The rate of Hp infection in patients with severe inflammatory response (85.7%) was higher than that in patients with moderate inflammatory response (39.7%)and mild inflammatory reactions (16.2%),the rate of Hp infection in patients with severe neutrophilic infiltrates (73.7%)was higher than that in mild subjects (29.1%).The rate of Hp infection in severe lymphocytic infiltrates (50.0%)was higher than that in mild patients (29.9%).The rate of Hp infection in patients with intestinal metaplasia (66.7%)was higher than that in those without intestinal metaplasia (26.8%).The rate of Hp infection in patients with intraepithelial neoplasia (83.3%)was higher than that in patients without intraepithelial neoplasia (30.5%).The differences were statistically significant (P <0.05).Conclusion The rate of Hp infection in patients with different types of gastritis is significantly different.The rate of Hp infection increases with the degree of inflammation,and Hp in-fection may promote the development of intestinal metaplasia and intraepithelial neoplasia.