血清甲胎蛋白水平检测联合增强CT检查对肝脏良、恶性肿瘤的鉴别诊断价值

摘要

To investigate value of serum alpha fetoprotein (AFP) combined with the enhanced CT scan in the differential diagnosis of benign and malignant tumors of liver. Methods:Forty-eight cases of patients with malignant liver tumors and 39 cases of patients with benign liver tumors diagnosed pathologically from January 2012 to January 2014 were selected, and the enhanced CT scanning was performed and serum AFP content was detected by chemiluminescence immune in all of them. Results:The sensitivity of differential diagnosis of the enhanced CT scan to benign and malignant hepatic tumor was 83.33%(40/48) with speciifcity 84.62%(33/39) and accuracy 83.91%(73/87), and the sensitivity of serum AFP in differential diagnosis of benign and malignant hepatic tumor was 72.92% (35/48) with specificity 89.74% (35/39) and accuracy 80.46%(70/87). The sensitivity, speciifcity and accuracy in differential diagnosis of both benign and malignant liver tumor rose to 95.83%(46/48), 97.44% (38/39) and 96.55% (84/87), respectively, a significantly higher improvement than those in single detection (P<0.05). Conclusion:The serum AFP combined with the enhanced CT scanning can improve the diagnosis rate of liver cancer, which has an important clinical value in the early treatment and is worthy of clinical use.%目的：探讨血清甲胎蛋白水平检测联合增强CT检查对肝脏良、恶性肿瘤的鉴别诊断价值。方法：选取2012年1月-2014年1月经病理组织学检查确诊的肝脏恶性肿瘤患者48例和肝脏良性肿瘤患者39例，对所有患者均进行增强CT检查及采用化学发光免疫法检测血清甲胎蛋白水平。结果：增强CT检查鉴别诊断肝脏良、恶性肿瘤的敏感性为83.33%（40/48）、特异性为84.62%（33/39）、准确性为83.91%（73/87），血清甲胎蛋白水平检测鉴别诊断肝脏良、恶性肿瘤的敏感性为72.92%（35/48）、特异性为89.74%（35/39）、准确性为80.46%（70/87）。增强CT检查联合血清甲胎蛋白水平检测鉴别诊断肝脏良、恶性肿瘤的敏感性、特异性和准确性分别提高至95.83%（46/48）、97.44%（38/39）和96.55%（84/87），均明显优于单项鉴别诊断结果（P均＜0.05）。结论：血清甲胎蛋白水平检测联合增强CT检查可提高肝脏良、恶性肿瘤的确诊率，对尽早选择正确的治疗方案具有重要的临床指导意义，值得推广应用。