Absrtact: Object vie To observe the INR of AF hyperuricemia patients 'prothrombin time under the situation where both allopurinol and warfarin are used to the treatment of anticoagulation . Methods A total of 240 patients with chronic permanent AF hyperuricemia were collected and then divided randomly into two groups:warfarin treatment group(120 cases), to maintain the original dose warfarin therapy and keep a low-purine diet;and the combined treatment group (120 cases), also in the conventional warfarin antithrombotic therapy and a low-purine diet, on this basis, plus allopurinol 100 mg, three times a day, which last for two weeks .Then observing and examining the change of the two group's INR after the treat-ment. Results The INR of the combined treatment group was obviously higher than the warfarin group ( P<0 .05 ) . Conclusion Allopurinol can increase antithrombotic effect of warfarin .INR should be monitored regularly during the treatment so as to adjust warfarin dosage accordingly .%目的：观察别嘌醇对应用华法林抗凝治疗的房颤合并高尿酸血症患者凝血酶原时间的国际标准化比值（ INR）的影响。方法收集华法林抗栓治疗的慢性永久性房颤合并高尿酸血症患者240例，随机分为两组。华法林治疗组（120例）维持原剂量华法林抗凝治疗，嘱低嘌呤饮食；联合治疗组（120例）在常规华法林抗栓治疗，低嘌呤饮食的基础上，加用别嘌醇100 mg，每日3次口服。治疗2周后，观察并检测两组患者治疗前后INR的变化。结果联合治疗组的INR较华法林治疗组明显增高（P＜0．05）。结论别嘌醇会增加华法林的抗栓作用，治疗过程中应定期监测INR，及时调整华法林用量。
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