药蜡治疗阿帕替尼所致手足综合征30例

摘要

Objective To investigate the clinical efficacy of Chinese herbal medicine and liquid wax in treating oral apatinib-induced hand-foot syndrome. Method Thirty patients with gastric or gastroesophageal junction adenocarcinoma, who had developed hand-foot syndrome after oral administration of apatinib for four weeks, with grade 0 in 3 cases, grade Ⅰ in 16 cases, grade Ⅱ in 9 cases and grade Ⅲ in 2 cases, were enrolled and treated by external application of Chinese herbal medicine and liquid wax on both hands and feet for three weeks. Result The 30 patients with hand-foot syndrome had grade 0 in 14 cases, grade Ⅰ in 14 cases, grade Ⅱ in 2 cases and grade Ⅲ in 0 case after treatment with Chinese herbal medicine and liquid wax. There was a definite therapeutic effect and a statistically significant difference (P<0.05). Conclusion External application of Chinese herbal medicine and liquid wax on both hands and feet for hand-foot syndrome not only has a definite therapeutic effect but is also an ideal means of prevention and treatment because of its noninvasive procedure and the high compliance of the patients.%目的：观察中药蜡液治疗口服阿帕替尼所致手足综合征的临床疗效。方法选取30例接受口服阿帕替尼治疗满4星期后出现手足综合征的胃腺癌或胃-食管结合腺癌患者,其中0级3例,Ⅰ级16例,Ⅱ级9例,Ⅲ级2例,均采用中药蜡液外敷双手足3星期。结果30例手足综合征患者在接受中药蜡液治疗后0级14例,Ⅰ级14例,Ⅱ级2例,Ⅲ级0例,疗效明确,且差异有统计学意义(P＜0.05)。结论中药蜡液外敷双手足治疗手足综合征不仅疗效明确,且因其为无创操作,患者依从性高,是理想的预防治疗手段。