Procedure for the production of New Derivatives of 2 - (3 - alquilcarbamoilfenil) - 6 - alquilcarbamoil - 4 - (3H) - quinazolonas as well as 2 - (3 - alquilcarbamoilfenil) - 6 - alquilcarbamoil - 4 - (3H) - quinazolonas

摘要

1333284 Quinazoline derived biscarbamates BAYER AG 11 Oct 1971 [13 Oct 1970] 47212/71 Heading C2C The invention comprises compounds of formula wherein X is O or S, R is alkyl (optionally with its C chain interrupted by O or S), cycloalkyl, aralkyl or aryl, RSP1/SP is alkyl, cycloalkyl or Ph, and any hydrocarbon radicals mentioned may be substituted. In examples, these compounds are prepared by reacting (1) the corresponding diisocyanate or diisothiocyanate with ROH, or (2) the corresponding diamine with ClCO 2 R, or (to obtain a product where R is 2-hydroxyethyl) glycol carbonate. Therapeutic compositions having cytostatic activity comprise compounds of the above formula, and may be administered orally, parenterally or rectally.