无溶剂条件下SbCl3催化合成二氢嘧啶酮衍生物

摘要

We synthesized a series of 3,4-dihydropyrimidinones with SbCI3 as a catalyst and no solvent. The acquired optimal reaction conditions are molar ratio of one aromatic aldehydes, one /3-dicarbonyl compound and one and a half urea, 0. 1 mol catalyst per mol aromatic aldehydes and reaction temperature 701C. This synthesis method has higher recovery rate and shorter reaction time and can deliver simpler operation, as compared with other traditional Biginelli reactions.%用SbCl3作催化剂,无溶剂条件下合成了一系列二氢嘧啶酮衍生物,确定了反应的最佳条件为芳香醛、β-二羰基化合物和尿素的摩尔比为1∶1∶1.5,催化剂用量为芳香醛的10％,最佳温度为70℃.探讨了反应机理.此方法收率高、反应时间短、操作简便.