Eco-Friendly Synthesis of Pyrimidine and Dihydropyrimidinone Derivatives under Solvent Free Condition and their Anti-microbial Activity

摘要

Reaction of 2-guanidinobenzimidazole and 2-guanidinebenzoxazole with several active methylene compounds revealed theformation of dihydropyrimidine and dihydropyrimidinone (DHPMs) derivatives via cyclo-condensation reaction. The productswere obtained in a good yield, short time and a simple experimental procedure. The synthesized compounds were evaluatedfor their anti-bacterial activity against Gram-positive and Gram-negative bacteria. The compounds exhibited excellent zone ofinhibition against tested bacteria. The investigation of antifungal screening data revealed that all the tested compounds showedmoderate to good fungal inhibition. All compounds have been characterized based on IR, 1H-NMR, 13C-NMR and Mass spectrumdata, in some cases the structure was established by X-Ray crystallography.