nm23-H１、CerbB-2的表达与食管癌预后的关系

摘要

91 ca ses of esophageal ca rcinoma，including 84 cases of squamousc arcinoma，3 cases of adenocarcinoma and 4 cases of undifferentiated small cell ca rcinoma were studied by immunohistochemi stry method.The results showed low rate of lymph node metastasis and h igh long term survival rate were found i n the group with high expression of nm23 -H１ or low expression of CerbB-2.In neg ative lymph node metastasis group，the ex pression of CerbB-2 was related to progn osis negative.%用免疫组化的方法分析91例食管癌（鳞癌84例，腺癌3例，未分化癌4例）转移抑制基因（nm23）和癌基因CerbB-2蛋白表达与肿瘤临床、病理各指标间的关系，探讨其在食管癌发生中的相互关系和影响。结果显示：转移抑制基因nm23-H１和原癌基因CerbB-2染色均定位于细胞浆，两者均与淋巴结转移、预后有显著相关性，两者表达无相关关系。在无淋巴结转移组，CerbB-2蛋白表达亦和预后有显著负相关。认为nm23-H１高表达或CerbB-2低表达者，淋巴结转移率低，术后生存率高，预后较好；CerbB-2可作为一个独立的预后指标，无论有无淋巴结转移，CerbB-2蛋白高表达预后均差。