目的 观察子痫前期(PE)孕妇甲状腺功能的变化.方法 174例子痫前期患者,其中轻度PE 83例,重度PE91例,另选择301例正常妊娠晚期妇女为正常对照组.采用电化学发光技术(ECL)检测血清TSH、FT4、TPOAb水平.结果 PE组TSH为2.69(0.58～12.88)mIU/L、FT4为12.13(8.65 ～17.06)pmol/L、TPOAb为12.55(5.0～98.36) IU/mL,正常对照组分别为2.14 (0.56 ～6.89) mIU/L、12.52 (9.30～17.14) pmol/L、8.03 (5 ～21.96) IU/mL,两组患者TSH、FT4、TPOAb相比P均＜0.05.PE组轻度PE患者TSH为2.41 (0.66 ～ 7.77) mIU/L、FT4为12.80(9.27 ～17.95)pmol/L、TPOAb为13.30 (5.0 ～ 102.79) IU/mL,重度PE患者分别为3.17(0.14～15.95) mIU/L、11.47(8.53～16.37)pmoL/L、11.20(5.0～150.02) IU/mL,轻重度PE患者TSH、FT4、TPOAb相比P均＜0.05.子痫前期孕妇血清TSH、TPOAb明显升高、FT4水平明显降低(P均＜0.05)；与轻度PE相比,重度PE孕妇血清TSH明显升高、FT4水平明显降低(P均＜0.05)；PE孕妇TPOAb阳性率达12.1％ (21/174),与同期筛查组相比P＞0.05;子痫前期患者合并各种甲状腺疾病,低T4血症发生率显著高于同期筛查组(P均＜0.05).结论 子痫前期患者血清TSH、TPOAb升高、FT4降低.%Objective To observe the thyroid function change in preeclampsia(PE) patients. Method A total of 174 women with PE were selected into PE group,and 301 healthy women in late pregnancy were selected into control group. The levels of TSH, FT4 and TPO-Ab were quantified by ECL. Results The serum TSH, FT4 and TPOAb in PE group were 2.69 (0.58-12.88) mIU/L,12.13 (8.65 ~17.06)pmol/L,12.55 (5.0-98.36) IU/mL; and 2.14 (0.56-6.89) mIU/L,12.52 (9.30 ~ 17.14) pmol/L,8. 03 (5 -21. 96) IU/mL in control group. Compared with control group, TSH and TPOAb in PE group raised and FT4 decreased(P<0.05 all). The serum TSH, FT4 and TPOAb in light PE patients were 2.41 (0.66 ~7.77)mIU/L,12. 80 (9. 27 - 17. 95)pmol/L,13. 30 (5.0-102.79) IU/mL; and 3. 17 (0.14-15.95) mIU/L,11.47 (8.53-16.37) pmol/L,11.20 (5.0-150.02) IU/mL in severe PE patients. Compared with light PE patients, the level of TSH and TPOAb in severe PE patients were higher, while FT4 were lower (P<0.05 all). The TPOAb positive rate was 12. 1% in PE group, but there were no significance between with normal control group. There were some kind of thyroid diseases could be combined in PE, especially hypothyroxinaemia. Conclusions The serum TSH and TPOAb raise and FT4 decrease in PE patients.
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