Objective To investigate the effects of serum levels of tumor necrosis factor alpha ( TNF-α) , soluble P55 (sTNFR-P55), transforming growth factor β1(TGF-β1) and soluble CD105(s-CD105), CCL20 chemokine and chemokine receptor CXCR3 on the illness change and prognosis of breast cancer patients .Methods 53 cases of patients with breast cancer recurrence and metastasis ( observation group ) , 42 cases of breast cancer without metastasis patients ( control group) , 36 cases of breast cancer patients ( operation group ) , and 41 individuals for health physical examination ( normal group) were included in the study .The serum TNF-α, sTNFR-P55, TGF-β1 , s-CD105 , CCL20, CXCR3 levels were meas-ured and compared among groups .Results There were significant differences of the serum TNF-α, sTNFR-P55, TGF-β1 , s-CD105, CCL20, CXCR3 between operation group preoperation and normal group (all P<0.05).The serum TNF-α, sT-NFR-P55, TGF-β1 , s-CD105 , CCL20, CXCR3 levels in the observation group were higher than those in the control group and the normal group (all P<0.05).The serum TNF-α, sTNFR-P55, TGF-β1, s-CD105, CCL20, CXCR3 levels in the local recurrence cases , lymph nodes metastasis cases , distant metastasis cases of the observation group had no significant differences (all P>0.05).Conclusion The levls of TNF-α, sTNFR-P55, TGF-β1, s-CD105, CCL20, CXCR3 in serum are closely related with illness change of breast cancer .%目的：探讨血清肿瘤坏死因子α（TNF-α）、可溶性受体P55（sTNFR-P55）、转化生长因子β1（TGF-β1）、可溶性CD105（ s-CD105）、趋化因子CCL20及趋化因子受体CXCR3在乳腺癌病情判断中的价值。方法选取乳腺癌复发转移患者53例（观察组）、未发生转移的乳腺癌患者42例（对照组）、乳腺癌手术患者36例（手术组）及健康体检者41例（正常组），将各组患者血清TNF-α、sTNFR-P55、TGF-β1、s-CD105、CCL20、CXCR3水平进行统计及比较。结果手术组术前与正常组比较，血清TNF-α、sTNFR-P55、TGF-β1、S-CD105、CCL20、CXCR3各指标存在统计学差异（ P均＜0．05）；观察组血清TNF-α、sTNFR-P55、TGF-β1、S-CD105、CCL20、CXCR3表达水平高于对照组及正常组，差异有统计学意义（P均＜0．05）；对照组与正常组各指标比较，差异无统计学意义（P均＞0．05）。观察组中局部复发组、淋巴结转移组、远处转移组各指标两两比较，差异无统计学意义（P均＞0．05）。结论血清TNFα、sTNFR-P55、TGF-β1、s-CD105、CCL20、CXCR3的水平与乳腺癌病情的变化密切相关，可作为监测乳腺癌患者有无复发和转移的重要指标。
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