目的：观察阿托伐他汀联合吉非罗齐治疗混合性高脂血症大鼠的疗效。方法将48只大鼠随机分为N、C、A、AJ组，每组12只；实验过程共8周，其中造模4周，用药4周。 N组普通饲料喂养，C、A、AJ组高脂饲料喂养；N、C组均不给予药物干预；A组晚间胃管给予阿托伐他汀1．8 mg/（kg· d），AJ组清晨胃管给予吉非罗齐54 mg/kg、晚间胃管给予阿托伐他汀0．9 mg/（ kg· d）。4、8周时检测血脂，8周时行肝脏病理学检查。结果4周时， C、A、AJ组TC、LDL-C、TG、LP-a均较N组升高（P均＜0．01）；8周时，A、AJ组TC、LDL-C、TG、LP-a均较C组降低（P均＜0．01），AJ组较A组HDL-C水平更高、TG水平更低（P均＜0．01）。 N组肝脏未见脂肪变性及坏死，C组脂肪变程度几乎达100％，A组脂肪变性程度明显减轻，AJ组脂肪变性较A组进一步好转。结论阿托伐他汀联合吉非罗齐可增强全面调脂疗效、控制炎症反应、减轻肝脏脂肪变性。%Objective To evaluate the efficacy of atorvastatin combined with gemfibrozil in treatment of combined hy -perlipidemia in rats.Methods Forty-eight Wistar rats were randomized into group N , group C, group A and group AJ, 12 rats in each group.The experimental process took 8 weeks, 4 weeks of modeling and 4 weeks of medication.The rats in each group were fed with high fatty food , except group N .Groups N and C were not given the drug intervention , but group A was administered with atorvastatin 1.8 mg/kg/d in the evening and group AJ was treated with atorvastatin 0.9 mg/kg/d +gemfi-brozil 54 mg/kg/d, respectively in the morning and in the evening .The plasma lipid were measured at week 4 and 8, moreo-ver, the hepatic pathological slices were observed at week 8.Results At week 4, the levels of TC, LDL-C, TG, Lp(a) in the groups C, A and AJ were higher than that of group N (all P<0.01);at week 8, the levels of TC, LDL-C, TG and Lp (a) of groups A and AJ were lower than that of group C (all P<0.01), the level of HDL-C was higher, and TG level was lower in the group AJ as compared with that of group A (all P<0.01).Group N showed no liver fatty degeneration and nec-rosis, but in group C, the steatosis was almost 100%, the degree of fatty degeneration significantly reduced in group A , and the fatty degeneration in group AJ improved better than that of group A .Conclusions Combined therapy of atorvastatin plus gemfibrozil can strengthen the effects on adjusting lipids , controlling the inflammation and relieving the fat degeneration in liv-er tissues of rats .
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