Objective To examine the variation of retinal thickness (RT) and light sensitivity (MS) of the macular central 10°regions of pathological myopic eyes , and further to analyze their correlations .Methods Sixty-five pathological myopic eyes of 50 patients without maculopathy were enrolled in this cross-sectional study .All patients underwent spherical equivalent (SE) and axial length (AL) measurement.Then fast macular thickness procedure of Cirrus HD-OCT was used to evaluate the RT of macular region .We only reserved the central 5 regions and recorded the RT of superior , temporal, in-ferior, nasal and central quadrant (RTs, RTt, RTi, RTn, RTc).Then the mean light sensitivity (MSw) was recorded a-mong all myopia eyes by using MAIA microperimetry .We divided the macular central 10°regions into 5 parts.The mean light sensitivity of each part (MSs, MSt, MSn, MSi, MSc) were also determined.The correlation between SE and AL, the correlation between RT and MS of corresponding part , the correlation between RT , MS and SE, AL were all analyzed .Re-sults Significant difference of RT in each section of central macular region was revealed by OCT test ( F=58.409, P=0.000).No significant difference of MS in each section of macular region was found (F=0.406, P=0.801).SE was negatively correlated with AL (r=-0.838, P=0.000).There was a positive correlation between RTs and SE (r =0.390, P=0.025), a negative correlation between RTs and AL (r=0.391, P=0.033), a negative correlation between RTn and AL (r=0.382, P=0.037).MSw was positively correlated with MS and SE (rw =0.329, P=0.029; rs =0.304, P=0.045;rt=0.323, P=0.033; ri =0.323, P=0.033; rn =0.325, P=0.031; rc =0.316, P=0.036). But no correlation was found between MS and AL .In the superior , inferior and nasal region , we also found a positive corre-lation between retinal thickness and light sensitivity (rs =0.420, P=0.019; ri =0.365, P=0.020; rn =0.381, P=0.013).Conclusions The macular retinal thickness distribution had disparity in the macular central 10°regions of patho-logical myopia .As the AL of eye increased , the RT at certain sections decreased .As the SE increased , all regions had a decreasing MS .%目的：检测病理性近视眼黄斑中心10°各区视网膜厚度（ RT）、光敏感度（ MS）变化，并分析其相关性。方法病理性近视黄斑区无特殊病变患者50例（65眼），均检测屈光度（SE）、眼轴长度（AL）；采用蔡司高分辨率光学相干断层扫描仪（Cirrus HD－OCT）行黄斑中心10°各区检测，记录上方、颞侧、下方、鼻侧、中央RT（RT上、RT颞、RT下、RT鼻、RT中）；采用MAIA微视野计行眼底成像、黄斑区微视野检测，记录黄斑中心10°上方、颞侧、下方、鼻侧、中央及总MS（ MS上、MS颞、MS下、MS鼻、MS中及MS总）；分析相关性。结果各区RT比较差异有统计学意义（ F＝58．409，P＝0．000），各区MS比较差异无统计学意义（F＝0．406，P＝0．801）。 SE和AL呈负相关（r＝－0．838，P＝0．000）；RT上与SE呈正相关（r＝0．390，P＝0．025）、与AL呈负相关（r＝－0．391，P＝0．033），RT鼻与AL呈负相关（r＝－0．382，P＝0．037），其余各区RT与SE、AL均无相关性（P均＞0．05）。 MS总、各区MS与SE均呈正相关（r总＝0．329，P＝0．029；r上＝0．304，P＝0．045；r颞＝0．323，P＝0．033；r下＝0．323，P＝0．033；r鼻＝0．325；P＝0．031，r中＝0．316，P＝0．036），与AL均无相关性（P均＞0．05）。除MS颞、MS中与相应区域RT无相关性外（P均＞0．05），其余各区MS与相应区域RT均呈正相关（r上＝0．420，P＝0．019；r下0．365，P＝0．020；r鼻0．381，P＝0．013）。结论病理性近视黄斑眼中心10°区RT分布存在区域性差异，随着AL增加某些区域选择性变薄；MS存在区域性差异，当近视度数增加时，各区域MS下降。
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