目的：探讨前列地尔联合还原型谷胱甘肽治疗急性肾损伤（AKI）的临床疗效。方法：选择 AKI 患者60例随机分为观察组与对照组，对照组30例在常规治疗基础上加用还原型谷胱甘肽治疗，观察组30例在对照组基础上加用前列地尔治疗，观察两组患者治疗效果与肾功能改善情况。结果：观察组患者治愈率为86．7％（26／30），显著优于对照组的63．3％（P＜0．05）；少尿型 AKI患者少尿期、多尿期持续时间、Scr 恢复时间显著短于对照组（P ＜0．05或 P＜0．01）；Scr 、Ccr 恢复情况不同时期比较观察组显著优于对照组（P＜0．05或 P＜0．01），治疗第28天观察组尿渗透压显著高于对照组、β2‐MG 显著低于对照组（P ＜0．01）。结论：还原型谷胱甘肽联合前列地尔对 AKI患者具有确切疗效，对改善肾功能方面具有积极治疗作用，可有效提高治愈率。%Objective :To discuss the clinical effects of alprostadil combined with glutathione in patients with AKI .Methods :60 patients with AKI were randomly divided into the observation group(n= 30) and the control group(n= 30) ,the control group were treated with Glutathione based on the conventional therapy ,and the observa‐tion group were given alprostadil based on the control group ,then the clinical effects were contrasted between the two groups .Results :Cure rate in the observation group was 86 .7% (26/30) ,significantly higher than 63 .3% (19/30) in the control group(P< 0 .05) ,in patients with Oliguric AKI ,Oliguria ,polyuria period duration ,and Scr re‐covery time in the observation group were significantly lower than the control group(P< 0 .05) ,in different periods , Scr and Ccr recovery in the observation group were significantly better the control group(P< 0 .05) ,Urine osmolali‐ty in the observation group was significantly higher than the control group 28 days after the treatment(P < 0 .01) , and β2‐MG significantly lower than the control group(P< 0 .01) .Conclusion :Alprostadil combined with glutathione has exactly effects in patients with AKI ,has positive therapeutic effect in the improvement of renal function ,it can effectively improve the cure rate .
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