替罗非班在急性 ST 段抬高型心肌梗死急诊 PCI 术前应用价值

摘要

Objective:To observe the safety and effect of tirofiban administered before an emergency per-cutaneous coronary intervention (PCI)for patients with acute ST-elevation myocardial infarction (STEMI).Meth-ods:120 patients with STEMI admitted to our hospital underwent emergent PCI,and were randomly divided into ob-servation group and control group,60 cases in each group.The two groups were compared regarding the application of aspiration catheter,TIMI flow grade,MBG grade,left ventricular function index and corrected TIMI frame count.Results:The application of aspiration catheter,TIMI flow grade and MBG grade in two groups showed sta-tistically significant difference (P <0.05).The left ventricular function and TIMI frame count in two groups showed statistically significant difference (P <0.05).Conclusions:Tirofiban can be safely administered before the PCI for patients with acute STEMI,and pre-PCI administration of this agent can boost the cardiac function and reducing the cardiovascular complications.%目的：：探讨替罗非班在急性 ST 段抬高型心肌梗死(STEMI)急诊 PCI 术前应用的安全性和效果。方法：选取来我院行 STEMI 急诊 PCI 治疗的患者120例，将其随机分为观察组(三联抗血小板组)和对照组(双联抗血小板组)，每组各60例。对照组患者于术前均嚼服600mg 氯吡格雷和300mg 阿司匹林，观察组患者于术前均嚼服300mg 氯吡格雷、300mg 肠溶阿司匹林联合替罗非班。比较两组患者的术后应用抽吸导管、TIMI 血流分级、MBG 分级、左室功能指标和校正 TIMI帧数。结果：观察组和对照组患者术后应用抽吸导管、TIMI 血流分级和 MBG 分级相比较，数据差异明显，有统计学意义(P 均<0.05)。观察组和对照组患者术后左室功能指标和 TIMI 帧数相比较，数据差异明显，有统计学意义(P 均<0.05)。结论：替罗非班在 STEMI 急诊 PCI 术前的应用效果良好，能有效减少缺血事件，改善患者心功能，安全有效。