含氯法齐明方案治疗耐多药肺结核近期疗效观察

摘要

Objective:Observation and evaluation including clofazimine solution treatment of multi‐drug resistant tuberculosis (before 6 month) recent effect .Methods:Selection 60 patients with multidrug‐resistant tuber‐culosis in our hospital ,were randomly divided into control group and treatment group and control group 30 cases , treatment group 30 cases .Treatment control group 6 Am ,Lfx ,X ,Y ,Z ,/12 Lfx ,Z ,X ,Y ;Treatment group:6 Z ,Am ,Lfx ,Cfz ,X ,Y /12 ,Lfx ,Cfz X ,Y ,Z .(X ,Y for sensitive drugs or according to antimicrobial suscepti‐bility test always unused anti‐tb drugs) .Results :Treatment group and control group in the treatment of the first 6 end phlegm germ feminine changed rate was respectively :56 .7% ,30 .0% (P < 0 .01) statistically significant ;Treatment group and control group in the treatment of the first of June lung imaging change:effective cases of 25 ca‐ses ,13 cases respectively ,effectiveness 80% ,50% respectively(P < 0 .01) ,with statistical significance .Conclu‐sion :Contain clofazimine solution treatment of multi‐drug resistant tuberculosis in the near future curative effect is distinct .%目的：观察和评价含氯法齐明方案治疗耐多药肺结核近期（治疗前6月）效果。方法：选取在我院的耐多药肺结核患者60例，随机分为对照组和治疗组，对照组30例采用6 Z、Am、Lfx、X、Y／12 Lfx、Z、X、Y治疗方案；治疗组30例采用6 Z、Am、Lfx、Cfz、X、Y／12 Z、Lfx、Cfz X、Y治疗方案。其中X、Y为根据药敏试验敏感的药物或既往未用过的抗结核药物。结果：治疗组和对照组在治疗第6个月末痰菌阴转率分别为56．7％、30．0％，两组比较具有极显著性差异（ P＜0．01）；治疗组和对照组在治疗第6个月末肺部影像学改变有效例数分别为24例、15例，有效率分别为80％、50％，两组肺部影像学改变有效率相比有极显著性差异（ P＜0．01）。结论：含氯法齐明方案治疗耐多药肺结核近期疗效显著。