雷公藤多苷联合缬沙坦治疗糖尿病肾病97例疗效观察

摘要

Objective: To observe the therapeutic effect of tripterygium glycosides in combination with valsartan on diabetic nephropathy.Methods: 196 patients with diabetic nephropathy were randomly divided into twogroups.The control group was orally given valsartan-and the treatment group was orally give tripterygium glycosides.Urine and blood routine index, and adverse reaction were observed.Results: After the treatment, urine and blood routine index were improved.Compared with the control group, the 24-hour urine protein and albumin the treatment group were significantly changed (P<0.05).Serious adverse reactions was not appeared in the treatment.Conclusion: Tripterygium glycosides in combination with valsartan is effective and safe to diabetic nephropathy, which is worth clinical promotion.%目的:探讨雷公藤多苷联合缬沙坦治疗糖尿病肾病的临床疗效.方法:将196例糖尿病肾病患者随机分为对照组和治疗组,对照组99例在常规化治疗的基础上,给予缬沙坦口服;治疗组97例在对照组的基础上,联合口服雷公藤多苷,观察比较两组患者治疗前后尿常规和血常规等变化,并观察其不良反应.结果:治疗后,两组患者尿常规和血常规等指标改善均优于治疗前(P<0.05).其中24 h尿蛋白低于治疗前,而血浆白蛋白水平高于治疗前,且治疗组24 h尿蛋白的降低效果显著优于对照组(P<0.05).未出现严重的不良反应.结论:雷公藤多苷联合缬沙坦能降低糖尿病肾病的尿蛋白水平,从而延缓糖尿病肾病的进展,安全有效.