PTEN--一种肿瘤抑制蛋白

摘要

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is an important tumor suppressor protein that can regulate signaling pathways in cell growth, proliferation, dif-ferentiation, apoptosis and migration. Its functions are regulated by oxidation of H2O2.%PTEN(10号染色体缺失的磷酸酶及张力蛋白同源物)作为一个重要的抑癌蛋白，其生物学功能主要体现在调节与细胞生长、增殖、分化、迁移和凋亡有关的信号通路上。在细胞中，PTEN 功能受到H2O2的氧化调节。