强骨胶囊对老年性骨质疏松症患者骨密度及骨转换生化指标的影响

摘要

Objective:To study the effect of Qianggu Jiaonang(强骨胶囊)on bone density and biochemical index of bone turnover in elderly patients with osteoporosis.Methods:120 cases of senile osteoporosis were randomly divided into a treatment group and a control group,60 cases in each.The control group was orally given Caltrate,while the treatment group was given Qianggu Jiaonang based on the treatment for the control group. The course of the two groups was half a year.The hip bone density,N-MID and β-CTX of the two groups were determined respectively before and after treatment.Results:After treatment,bone density of the femoral neck,Wards triangle and greater trochanter in the two groups were improved in different degrees,but the difference before and after treatment in the treatment group was statistically signiifcant (P< 0.05),while the difference in the control group was not statistically signiifcant (P> 0.05).After treatment,the difference between the two groups had statistical significance(P< 0.05).In the treatment group,N-MID increased and β-CTX decreased after treatment,the difference being statistically significant(P< 0.05);while in the control group,the differences respectively between N-MID and β-CTX were not statistically signiifcant (P> 0.05) after treatment.There were no serious adverse reactions in the two groups during the treatment.Conclusion:Qianggu Jiaonang combined with calcium can improve the bone density in elderly patients with osteoporosis by enhancing bone formation and inhibiting bone resorption,effective and safe.%目的：探讨强骨胶囊对老年性骨质疏松症患者骨密度及骨转换生化指标的影响。方法：将120例老年性骨质疏松症患者随机分为治疗组和对照组，每组60例。对照组给予口服碳酸钙D3治疗，治疗组在对照组治疗基础上加服强骨胶囊。2组1个疗程均为半年。分别测定2组患者治疗前后髋部骨密度、空腹血清中骨钙素N端中分子片段（N-MID）和β-胶原降解产物（β-CTX）的变化情况。结果：治疗后，2组患者股骨颈、Wards三角区、大转子骨密度均有不同程度的提高。治疗组治疗前后比较，差异有统计学意义（P <0.05）；对照组治疗前后比较，差异无统计学意义（P >0.05）。治疗后，2组间比较，差异有统计学意义（P <0.05）。治疗前后比较，治疗组N-MID升高、β-CTX降低，差异有统计学意义（P <0.05）；对照组N-MID、β-CTX改变差异无统计学意义（P >0.05）。治疗过程中2组患者均未发生严重不良反应。结论：强骨胶囊联合碳酸钙D3可通过增加骨形成、抑制骨吸收来提高老年性骨质疏松症患者髋部骨密度，效果明显、安全性好。