HIV感染者认知功能正常时静息态脑功能连接的研究

摘要

Objective:The purpose of this study was to investigate whether there is any abnormality in the resting state brain network connection in HIV infected patients with normal cognitive function compared with normal subjects.Methods:According to the inclusion criteria,25 patients with HIV infection and 27 normal subjects were collected.The differences in Montreal cognitive assessment score,age,gender,and education level were compared.The resting brain function technique was used as the seed point in the bilateral brain regions.Difference of each seed point connected with the whole brain network between the two groups was analyzed.The voxel P was 0.005 and the cluster P was 0.05.Results:Difference between the two groups was statistically significant in each of the seed points;there were significant differences in the 8 brain regions of the 19 seed points after multiple correction.The function connectivity between the seed points and the whole brain were higher in HIV infection group than that in normal group in the left medial frontal,bilateral hippocampus,bilateral anterior cingulate gyrus,left parietal lobe,left thalamus,and left fusiform gyrus.The function connectivity was lower in the bilateral visual cortex of the occipital and left insula.Either higher or lower in the right motor cortex and the left low parietal lobe.Conclusion:There is a significant difference in the resting state brain network connectivity between HIV infected patients with normal cognitive function and normal subjects.It suggests that HIV infected individuals may have abnormal brain function connections during normal cognitive function,and that the HIV virus may affect brain function connections.%目的:探讨认知功能正常时HIV感染者与正常人的静息态脑功能连接情况.方法:按照入选标准搜集25例HIV感染者和27例健康志愿者作为正常对照组,比较蒙特利尔认知评估量表评分、年龄、性别、教育水平的差异.应用静息态脑功能技术以双侧大脑各区为种子点,分析两组各种子点与全脑功能连接的差异,体素P取0.005,团簇P取0.05.结果:HIV感染组与正常对照组各种子点均有统计学差异,经多重校正后有19个种子点8个脑区差异具有统计学意义.HIV感染组在以左侧额极内侧、双侧海马、双侧前扣带回、左侧顶叶、左侧丘脑、左侧梭状回的种子点与全脑的功能连接高于正常组;HIV感染组在以双侧视觉皮层枕叶、左侧岛叶区域的种子点与全脑的功能连接低于正常组;HIV感染组在以右侧运动皮层、左侧顶下叶的种子点与全脑的功能连接与正常组比较既有升高又有降低.结论:HIV感染者认知功能正常时的静息态脑功能连接与正常人有显著差异,提示HIV感染者在认知功能正常时脑功能连接可能已经出现异常,HIV病毒可能影响脑功能的连接.