水痘-带状疱疹病毒对系统性红斑狼疮患者体液免疫功能的影响

摘要

目的:观察水痘患者、系统性红斑狼疮(systemic lupus eryhematosus,SLE)患者和系统性红斑狼疮合并水痘患者体液免疫指标的变化,探讨水痘-带状疱疹病毒对系统性红斑狼疮患者体液免疫功能的影响.方法:选择在我院诊断治疗的水痘患者、系统性红斑狼疮患者和系统性红斑狼疮合并水痘患者共66例,同时设21例正常对照组；利用血液细胞分析仪检测各组血液中白细胞计数(WBC)、血小板计数(PLT)以及血红蛋白含量(HGB)；采用免疫比浊法检测各组血清中免疫球蛋白G(IgG)、免疫球蛋白A(IgA)和免疫球蛋白M(IgM)以及补体C3、C4的水平.结果:与正常对照组比较,水痘组、SLE组以及SLE合并水痘组WBC、PLT和HGB含量下降,其中SLE组和SLE合并水痘组WBC、PLT降低,差异有统计学意义(P＜ 0.05或P＜0.01)；水痘组血清中IgG、IgA和IgM含量下降,SLE组和SLE合并水痘组血清中IgG、IgA和IgM含量上升,其中水痘组血清中IgA含量减少有统计学意义(P＜0.05),SLE组和SLE合并水痘组血清中IgG、IgA含量增加有统计学意义(P＜0.05或P＜0.01)；水痘组血清中补体C3、C4含量增加,SLE组和SLE合并水痘组血清中补体C3、C4含量减少,其中SLE合并水痘组减少且差异有统计学意义(P＜0.05).与SLE组比较,SLE合并水痘组WBC明显增加(P＜0.05),血清中IgG、IgA和补体C3、C4降低且差异有统计学意义(P＜0.05).结论:水痘-带状疱疹病毒可引起系统性红斑狼疮患者免疫系统相关指标的改变并对其产生影响.%Objective: To observe the immunological indexs' changes of patients with chickenpox, systemic lupus erythematosus and systemic lupus erythematosus with chickenpox, and to explore the effect of varicella-zoster virus on the immune system of patients with systemic lupus erythematosus. Methods: A total of sixty-six cases of patients with chickenpox, systemic lupus erythematosus and systemic lupus erythematosus with chickenpox were chosen, and Diagnosis and treatment of chickenpox in our hospital patients, with systemic lupus erythematosus and systemic lupus erythematosus chickenpox patients, twenty-one cases of normal control group were set at the same time; The white blood cell count (WBC), platelet count (PLT) and hemoglobin content (HGB) in every group were detected using blood cells analyzer; The levels of immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) and C3, C4 in serum of every group were detected using immunoturbidimetric assay method. Results: Compared with the control group, the levels of WBC, PLT and HGB in groups of varicella, SLE and SLE with varicella were decreased, and the reduction of WBC and PLT in group of SLE and SLE with varicella had statistical significance (P < 0.05 or P <0.01); The content of IgG, IgA and IgM in serum of varicella group decreased while the group of SLE and SLE with varicella increased, and the reduction of IgA in serum of varicella group had statistical significance (P < 0.05) while the increase of IgG and IgA in group of SLE and SLE with varicella had statistical significance (P < 0.05 or P < 0.01); The levels of C3 and C4 in serum of varicella group increased while the group of SLE and SLE with varicella decreased, and the reduction of C3 and C4 in group of SLE with had statistical significance (P < 0.05). Compared with the SLE group, the increase of WBC had statistical significance (P < 0.05) in SLE with varicella while the levels of IgG, IgA, C3 and C4 in serum decreased with statistical significance (P < 0.05). Conclusion: Varicella-zoster virus can induce the changes of immune system-related indexes in systemic lupus erythematosus patients.