质子泵抑制剂兰索拉唑和奥美拉唑对胃溃疡患者MDA,SOD及NO的影响

摘要

目的:探讨兰索拉唑和奥美拉唑两种不同质子泵抑制剂对胃溃疡患者治疗效果及对丙二醛(MDA)、超氧化物歧化酶(SOD)及一氧化氮(NO)水平的影响.方法:收取2013年9月至2015年6月之间于我院接受治疗的胃溃疡患者98例作为研究对象,根据随机数字表法将98例患者平均分为A、B两组,两组各包含患者49例.A组患者使用兰索拉唑治疗,B组患者使用奥美拉唑治疗,两组均进行连续30d治疗.对两组患者治疗效果、症状缓解情况、MDA、SOD及NO水平、不良反应以及治疗费用进行比较.结果:A组患者痊愈率及总有效率分别为63.27％及91.84％,B组患者痊愈率及总有效率分别为61.22％及93.88％.两组患者治疗效果比较无显著差异(P＞0.05).治疗后,两组患者腹胀、腹痛、上腹部烧灼及反酸症状与治疗前相较有显著差异(P＜0.05),但治疗后组间比较无明显差异(P＞0.05).治疗后两组MDA显著降低,SOD及NO显著升高,其中A组变化幅度大于B组,差异有统计学意义(P＜0.05).A组患者不良反应发生率为20.41％,明显高于B组的6.12 ％(P＜0.05).B组患者质子泵抑制剂治疗费用明显低于A组.结论:兰索拉唑和奥美拉唑两种质子泵抑制剂对胃溃疡患者疗效相当,兰索拉唑在MDA、SOD及NO水平改善上具有优势,但奥美拉唑安全性更高且治疗费用相对较低.应当结合患者具体情况选择适宜的治疗方案.%Objeetive:To compare the clinical effect of two proton pump inhibitors (PPIs) Lansoprazole and Omeprazole in treatment of gastric ulcer and the influences on MDA,SOD and NO level.Methods:98 gastric ulcer patients accepted in our hospital from September 2013 to June 2015 were selected and randomly divided into group A and B with 49 cases in each group.49 patients in group A were given lansoprazole,and 49 patients in group B were given omeprazole for 30 days.Then the clinical effect,symptoms remission,and the expression level of MDA,SOD and NO,the incidence of adverse reactions and the medical cost were compared.Results:The cure rate and total effective rate was 63.27 ％ and 91.84 ％ respectively in group A,and it was 61.22 ％ and 93.88 ％ respectively in group B.The clinical effect of two groups had no big difference (P＞0.05).The symptoms of bloating,bellyache,epigastrium burn feel and acid reflux of two groups after treatment were getting better than before treatment with statistically significance (P＜0.05),but there was no big difference between two groups after treatment (P＞0.05).The expression level of MDA after treatment of 2 groups were decreased,SOD and NO were increased.The extent of variation of group A was obviously greater than that of group B with statistically significance (P＜0.05).The expression level of MDA,SOD and NO were all getting better after treatment,and it was better in group A than group B (P＜0.05).The adverse reaction rate of group A was 20.41％,which was obviously higher than 6.12 ％ of group B (P＜0.05).The medical cost of group B was less than that of group A.Conclusions:The two PPIs Lansoprazole and Omeprazole have same effect in treatment of gastric ulcer.Lansoprazole has advantages in improving the expression levels of MDA,SOD and NO,but omeprazole is more safety and less medical cost.So the proper drugs should be chosen according to the actual situation of the patients.