汉坦病毒感染对Ⅰ型干扰素应答的调节机制

摘要

汉坦病毒主要感染人内皮细胞，细胞在病毒感染早期诱导生成的Ⅰ型干扰素( IFN-Ⅰ)可阻断汉坦病毒的复制，但不同的病毒蛋白和不同型别的汉坦病毒在IFN应答的调节机制上可能有所不同。就汉坦病毒感染对IFN应答的调节机制进行了综述。%Hantaviruses primarily infect human vascular endothelial cells ( VECs) , and type I interferon ( IFN) which is induced by Hantavirus infection in early phase can block the replication of Hantavirus, but the different viral proteins and different types of Hantavirus may play the different role in the regulation of IFN response. This paper reviews the regulation mechanism of IFN responses by Hantavirus infection.