Protease catalyzed peptide syntheses in organic solvents have been proved to be successful. In this article, some elemental concepts on the enzymatic syntheses are introduced and new strategies to broaden the use of protease in organic syntheses are reviewed.%介绍了有机溶剂中酶促反应的一些基本概念,总结了酶促反应的发展情况,归纳了近几年来将蛋白酶应用于有机合成的一些新策略。
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