近紫外光辅助4-硫脱氧胸苷抗癌作用的研究

摘要

This article reviews the developments of 4-thiothymidine analogues,assisted with UVA light,as a novel cancer therapy.First,the key points on synthetic chemistry,photochemistry and cellular toxicity of 4-thiothymidine are summarized.As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine,thus 4-thiothymidine can be readily incorporated into cellular DNA,and with the help of thymidine kinase,much more preferably into cancerous DNA.Unlike thymidine,4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light.Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment.Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed.The various interactions between 4-thiothymidine with human serum albumin are introduced.Finally,a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given.%4-硫脱氧胸苷(4-thiothymidine,S4TdR)作为硫代类核苷类似物的典型代表,其具有较强的亲脂特性和强的紫外长波长(315～400 nm,UVA)吸收.这些特性使得4-硫脱氧胸苷能够靶向进入肿瘤细胞并以核苷酸的形式嵌入DNA链中,在近紫外UVA的辅助下发生光化学反应,损伤肿瘤细胞DNA,诱导细胞走向凋亡途径,达到抗癌的目的.本文系统地介绍和评述了长波紫外光/含硫脱氧胸苷(UVA/thiothymidine)的抗癌疗法及原理,探讨4-硫脱氧胸苷与人血清蛋白间的相互作用,为这种新型光化学疗法在今后的癌症治疗中提供基础的理论依据.