Objective:To investigate the effect of penehyclidine hyrochloride and positive end - expiratory pressure (PEEP)on respiratory function during gynecologic laparoseopic surgery. Methods:Eighty patients scheduled for gynecologic laparoscopic surgery under general anesthesia were randomly divided into four groups with each group 20 cases:group Ⅰ was treated with intravenous injection of 1 mL saline at 1 0 min before intubation ,PEEP value was set to 0 cm H2 O( 1 cm H2 O =0. 098 kPa);group Ⅱ was intravenous injection of 1 mg penehyclidine hyrochloride at 10 min before intubation,PEEP value was set to 0 cm H2 O;group Ⅲ was 1 mL saline and PEEP value was set to 5 cm H2 O;group Ⅳ was 1 mg penehyclidine hyro-chloride and PEEP value was set to 5 cm H2 O. Plat pressure( Plat),peak airway pressure( Peak),respiratory resistance (Raw),partial pressure of carbon dioxide in endexpiratory gas(PetCO2 )and arterial blood gas were recorded before injection (To),before pneumoperitoneum(T1),at 30(T2),60(T3)nmin after pneumoperitoneum and at 10min after anesthesic(T4). Results:Plat,Peak,Raw increased significantly(P < 0. 01)after pneumoperitoneum in four groups,and groupⅡ < group Ⅳ 展开▼
