莫西沙星治疗国内社区获得性肺炎的Meta分析

摘要

目的 利用Meta分析方法对莫西沙星治疗国内社区获得性肺炎(CAP)的临床试验进行分析,评价其治疗效果.方法 检索2002-2010年在国内生物医学期刊发表的有关莫西沙星治疗社区获得性肺炎的临床研究文献,采用Review Manager 4.2软件对符合条件的文献进行荟萃分析.结果 共有19个临床试验纳入本次研究,同质性检验X2=0.30,P>0.05,故采用固定效应模型进行分析.与对照组比较,莫西沙星治疗社区获得性肺炎总有效率更高,比值比为1.94,95%可信区间为1.32-2.84(P<0.05).结论 临床可选用莫西沙星治疗社区获得性肺炎.%Objective To conduct a meta-analysis on the clinical trails of moxifloxacin for dome.stical community-acquired pneumonia and evaluate its outcome. Methods Related literature concerning clinical trials of moxifloxacin in treating community-acquired pneumonia published domestically from 2002 to 2010 were retrieved. Meta analysis on the selected literature was conducted by means of Review Manager 4. 2 software. Results A total of 19 clinical trials were included in our study(homogeneity testx2 =0. 30,P ＞0. 05) ,thus a fixed effect model was applied. Compared with the control group,moxifloxacin has a higher total effective rate with the odds ratio at 1.94 and 95％ confidence interval at 1.32 - 2. 84( P ＜ 0. 05). Conclusion Moxifloxacin can be used as an option in the treatment of communityacquired pneumonia.