目的 对比分析兰索拉唑与奥美拉唑治疗酒精型消化性溃疡的临床疗效.方法 将126例酒精型消化性溃疡患者随机分入兰索拉唑组与奥美拉唑组,兰索拉唑组给予兰索拉唑+阿莫西林+克拉霉素治疗,奥美拉唑组给予奥美拉唑+阿莫西林+克拉霉素治疗,两组疗程均为4周.比较两组的临床疗效、幽门螺杆菌(Hp)清除率及不良反应发生率.结果 兰索拉唑组与奥美拉唑组临床治疗总有效率分别为95.5%和95.0%,两组比较差异无统计学意义(P>0.05);两组患者治疗前后临床症状比较差异无统计学意义(P>0.05);兰索拉唑组Hp清除率显著高于奥美拉唑组(90.9% vs.78.3%,P<0.05);兰索拉唑组与奥美拉唑组不良反应发生率比较差异无统计学意义(7.6% vs.13.4%,P>0.05).结论 兰索拉唑治疗酒精型消化性溃疡Hp清除率高,不良反应少.%Objective To compare the clinical efficacy of lansoprazole and omeprazole in treatment for alcoholic peptic ulcer. Methods 126 cases with alcoholic peptic ulcer were randomly divided into lansoprazole group and omeprazole group. Lansoprazole group received lansoprazole, amoxicillin and clarithromycin treatment. Omeprazole group was given omeprazole, amoxicillin and clarithromycin treatment. Clinical effect, Hp eradication rate and adverse reaction rate were compared between the two groups. Results The effective rates in lansoprazole group and omeprazole group were 95. 5% and 95. 0% respectively ( P >0. 05 ); There was no significant difference in clinical symptoms before and after treatment between the two groups ( P > 0. 05 ); Hp eradication rate in lansoprazole group was much higher than that in omeprazole group( 90. 9% vs 78. 3% ,P <0. 05 );The adverse reaction rates were 7. 6% and 13. 4% in lansoprazole group and omeprazole group without significant difference ( P > 0. 05 ). Conclusion Lansoprazole treatment for alcoholic peptic ulcer has high eradication rate and low adverse reaction rate.
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