尼莫地平联合舍曲林治疗仅有血管危险因素的抑郁症的研究

摘要

目的 观察尼莫地平联合舍曲林治疗仅有血管危险因素的抑郁症的临床疗效.方法 选择我院2009年6月至2012年6月抑郁症患者200例,随机分为尼莫地平、舍曲林联用组(联合组)与单用舍曲林组(对照组).分别于治疗前和治疗后1、2、4、6、8周末记录两组汉密尔顿抑郁量表(HAMD)、简明智能状态量表(MMSE),比较两组疗效.结果 治疗后,两组HAMD、MMSE评分均改善(P<0.05),且联合组明显优于单用舍曲林组(P<0.05).结论 尼莫地平联合舍曲林治疗仅有血管危险因素的抑郁症疗效显著.%Objective To explore the clinical efficacy of nimodipine combined with sertraline in the treatment of depression with only vascular risk factors. Methods Two hundred depression patients of our hospital from June 2009 to June 2012 were randomly divided into two groups. Patients in combination group were given nimodipine and sertraline, while patients in control group received only sertraline. HAMD and MMSE were used to evaluate the efficacy of the two groups. Results The scores of HAMD and MMSE of the two groups were improved after treatment(P < 0.05 ),and there were significant differences between the two groups. Conclusion Nimodipine combined with sertraline has better effect in the treatment of depression with only vascular risk factors.