目的：对比评价马来酸噻吗洛尔与布林佐胺联合曲伏前列素治疗开角型青光眼和高眼压症的临床疗效。方法将我院使用曲伏前列素单药治疗效果不佳的开角型青光眼与高眼压的76例患者分为S组和B组,S组38例(38眼)患者在曲伏前列素基础上合用马来酸噻吗洛尔治疗,B组38例(38眼)患者则合用布林佐胺治疗,于2周和1、3、6个月随访。对比观察两组治疗前后的平均眼压、昼夜眼压差、心率、血压和不良反应发生情况。结果两组患者在联合用药后2周和1、3、6个月平均眼压下降,与治疗前比较差异均有统计学意义(P0．05)；S组联合用药后6个月昼夜眼压差较B组大,两组差异有统计学意义(P0．05)；B组患者心率在联合用药前后无明显变化(P>0．05),S组患者心率则在随访6个月时出现明显心脏抑制(P0. 05). The difference of diurnal IOP was significant between the two groups after 6 months of combination therapy(P0. 05). The heart rate did not change significantly,and the patients of group S showed significant cardiac depression after 6 months follow-up (P<0. 05). No serious adverse events occurred in both groups. Conclusion The clinical efficacy would significant when it is trea-ted for open-angle glaucoma and ocular hypertension,either timolol maleate or brinzolamide combined travopros,and the clinical efficacy would be stable and safe when brinzolamide is applied than timolol maleate.
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