脂质组学在结直肠癌研究中的应用

摘要

Colorectal cancer is one of the most common malignant tumors in China. It poses a serious threat to health and its morbidity and mortality are increasing year by year. There are defects in early diagnostic markers and disease activity progression indi-cators for clinical applications. Lipidomics helps to analyze the etiology,pathological progression and clinical diagnosis of colorectal cancer by comparing differences in lipid metabolites in vivo,providing a new method and platform for research of colorectal cancer. This review is aimed at the application of lipidomics in colorectal cancer.%结直肠癌是我国目前常见的恶性肿瘤之一,对健康造成了严重威胁,其发病率和死亡率呈逐年上升的趋势.临床应用的早期诊断标志物和疾病活动进展指标存在缺陷.脂质组学通过比较体内脂质代谢物变化特征差异,帮助分析结直肠癌病因、病变进展及辅助临床诊断,为结直肠癌研究提供新方法和平台,本综述对脂质组学在结直肠癌研究中的应用进行论述.