肺癌相关的 Slit2－Robo1信号通路的研究进展

摘要

Tumor growth and migration are correlated with continuous neovascularization .Slit2-Robo1 signal pathway initially positioned in the nervous system plays an important role in the growth and neuronal axon guidance during migration.However,vascular system resembles the structural features and growth mechanism of neural system .Recent researches have shown that Slit 2-Robo1 signaling pathway plays an important role in vas-cular system,especially in tumor vessel .And Slit2-Robo1 has been shown to play a role in brain metastasis in breast cancer and supporting tumor growth in melanoma .Therefore,the role of Slit2-Robo1 in tumor growth and migration depends on the cancer type .Currently ,researches in this field show controversial results .And the status of Slit2-Robo1 signaling pathway in lung cancer is reviewed in this essay .%恶性肿瘤的生长和转移离不开新生血管的形成。 Slit2－Robo1信号通路最初是在神经系统中被发现，且在轴突导向生长和神经细胞迁移过程中发挥重要作用，血管系统和神经系统的结构和功能具有相似之处，近年来研究发现Slit2－Robo1信号通路在血管系统，特别是肿瘤血管中具有重要的作用，并在不同肿瘤中发挥的作用不同，已发现Slit2－Robo1可以抑制乳腺癌脑转移的扩散，同时，Slit2－Robo1也可以促进黑素瘤中的肿瘤生长。本文对与肺癌相关的Slit2－Robo1信号通路现状做一综述。