血清性激素水平和体重指数与绝经后女性乳腺癌发病的相关性研究

摘要

目的：探讨绝经后女性乳腺癌的发病与血清性激素水平和体重指数的关系。方法选择2013年3月—12月在哈尔滨医科大学附属肿瘤医院乳腺外科接受手术治疗的初诊绝经后乳腺癌118例作为病例组以及60例绝经后乳腺良性病变者作为对照组，并收集所有受试对象的身高、体重等基本资料。应用酶联免疫吸附实验（ELISA）方法检测受试对象的血清雌二醇（Estradiol，E2）、雌酮（Estrone，E1）、睾酮（Testesterone，TSTO）以及雄烯二酮（Androstenedione，AED）水平，并对结果进行分析。结果病例组血清E2、E1、AED水平显著高于对照组（ P＜0．05），病例组的血清TSTO平均水平稍高于对照组，但差异无统计学意义（P＞0．05）；病例组体重指数（BMI）与对照组无明显差异（P＞0．05）；病例组血清E1以及总研究对象的血清E1、TSTO、AED在超重组内的水平明显高于非超重组（P＜0．05），未发现其余各组的激素水平与BMI指数具有相关性（P＞0．05）。结论绝经后女性乳腺癌患者的血清性激素水平升高，血清E2、E1、AED水平升高可能是与绝经后女性乳腺癌的发病相关，BMI高的绝经后女性的血清性激素水平较高。%Objective To investigate the association between serum sex hormone levels as well as body mass index and breast cancer in postmenopausal women .Methods We selected the cases of postmenopausal women who accepted surgical treatment for the first time which from March 2013 to December 2013 in the depart-ment of breast surgery the Affiliated Tumor Hospital of Harbin Medical University ,of which 118 cases of patients with breast cancer and 60 cases of benign breast lesions as control group .Meanwhile,information of body height and weight.were collected.Serum estradiol(E2),estrone(E1),testosterone(TSTO)and androstenedione(AED) concentrations were measured in 118 postmenopausal women with breast cancer patients and 60 matched control subjects by enzyme-linked immunosorbent assay(ELISA),then the results were estimated.Results The levels of serum E2,E1,AED of breast cancer group were significantly higher than those in control group (P<0.05). The serum level of TSTO in cases group was higher than the control group ,but the results were not statistically significant(P>0.05).The levels of body mass index(BMI)were not statistically significant(P>0.05)between breast cancer group and the control group .The level of E1 in breast cancer group and levels of E 1,TSTO,AED in overall of overweight group were significantly higher in overweight (P<0.05),yet we have not found association between levels of hormone and BMI .Conclusion The level of serum sex hormones is higher with breast cancer in postmenopausal women ,while high serum levels of E2,E1,AED maybe associated with breast cancer in postm-enopausal women .Sex hormones are higher in postmenopausal women with high BMI .