H E4在浆液性卵巢癌组织中的表达及与临床病理因素的关系

摘要

Objective To investigate the expression level of human epididymis protein 4 ( HE4 ) in se-rous ovarian cancer tissues and its relationship with clinicopathological features .Methods The expression level of HE4 in 140 serous ovarian cancer patients and its relationship with clinicopathological features were detected by immunohistochemistry.To compare the correlation between HE4 and CA125, the histological expressionOf CA125 was also detected by IHC .Results the positive expression rate of HE 4 and CA125 in moderately and poorly differentiated serous ovarian cancer tissues were respectively 89.76%and 81.89%;the positive expression rate in well differentiated group were respectively 46.61% and 15.38%,in the advanced stages were 92.44%and 83.19%,in the early stages were 47.62%and 33.33%.the positive expression rate of lymphatic metastasis were 95.65%and 84.35%,without lymphatic metastasis were 40.00%and 36.00%,the positive expression rate of peritoneal implantation were 90.00% and 87.27%, without peritoneal implantation were 70.00% and 33.33%;the positive expression rate of ascites were 89.76% and 79.53%,without ascites were 46.15% and 38.46%.Besides,the positive expression rates of HE4 and CA125 were 86%and 76%,the differences were sta-tistically significant.Both the positive expression in ovarian cancer are correlated positively (P<0.05).The ex-pression of HE4 and CA125 has nothing with the occurrence of pausimenia and the number of parity in patients with ovarian cancer(P>0.05).Conclusion The expression of HE4 in serous ovarian cancer is related with FI-GO stages,the degree of tumor differentiation ,lymph node metastasis and ascites .%目的：探讨人附睾分泌蛋白4（ HE4）在浆液性卵巢癌组织中的表达及与临床病理因素之间的关系。方法应用免疫组化的方法检测HE4在140例浆液性卵巢癌组织中的表达情况及与临床病理因素的关系，并联合检测CA125在卵巢癌中的组织学表达情况，对比HE4与CA125的相关性。结果HE4和CA125在中低分化浆液性卵巢癌组织中的阳性表达率分别为89．76％和81．89％，在高分化者阳性率分别为46．61％和15．38％，中晚期卵巢癌者阳性率为92．44％和83．19％，早期卵巢癌者阳性率为47．62％和33．33％，有盆腔淋巴结转移者阳性率95．65％和84．35％，无盆腔淋巴结转移者40．00％和36．00％，有腹腔种植者阳性率90．00％和87．27％，无腹腔种植者70．00％和33．33％，卵巢癌合并腹水者阳性率89．76％和79．53％，无腹水者为46．15％和38．46％，另外，HE4和CA125在浆液性卵巢癌中的阳性表达率分别为86％和76％，差异均具有统计学意义（ P＜0．05），两者在卵巢癌的阳性表达上存在相关性（P＜0．05）。 HE4和CA125的表达与卵巢癌患者是否绝经和产数无关，（P＞0．05）。结论 HE4在浆液性卵巢癌组织中的表达与FIGO分期、肿瘤分化程度、淋巴结有无转移、腹腔有无种植和是否合并腹水有关。