非小细胞肺癌局限性脑转移的治疗现状及研究进展

摘要

The single brain metastases of lung cancer is defined as limited brain metastases .Mechanism of brain metastasis from lung cancer remains to be further studied .Based on surgery ,radiotherapy ,and chemother-apy,the comprehensive treatment on limited brain metastasis of non -small cell lung cancer gets a better result , however ,the indications for combination therapy must be strictly controlled .Increasing radiation doses of local tumor area,followed by whole-brain radiotherapy,can improve tumor local control rate and prolong overall sur-vival.Prophylactic irradiation of whole brain showed no evidence on prolonging the overall survival .For patients with poor general state,targeted drugs combined with whole brain radiotherapy can be tolerated well ,as well as prolonged the overall survival to ertain extent .%癌症经查证仅存在脑部转移称为局限性脑转移。肺癌的脑转移分子调控机制尚待进一步研究，以手术、放疗、化疗为基础的非小细胞肺癌局限性脑转移综合治疗的效果较好，但联合治疗的适应证需严格掌握。全脑放疗后肿瘤区局部增加照射剂量有利于提高肿瘤局控率，延长整体生存；脑预防照射未见生存期的明显延长。靶向药物联合全脑放疗对于一般状态较差的患者耐受性较好，且生存期得到了一定的延长。