P300／CBP 在恶性肿瘤中的研究进展

摘要

P300/CBP is one of the most important high molecular weight protein histone acetyltransferase ( HAT) Although it is encoded by multiple different genes , P300/CBP is highly homologous , Because they have the similar amino acid sequence and functions ,and belong to the same class of proteins ,normolly they are all called P300/CBP.P300/CBP is involved in the activation of many kinds of transcription factors ,the protein itself alsohas acetyltransferase activity ,and is capable of acetylation of 4 core histones and transcription factor .More and more studies have confirmed the relationship of P 300/CBP variation withmultiple human diseases , including in-flammation,diabetes,heart disease and especially cancer .In tumor P300/CBP is associated with some pathways , and these pathways play a different roles in the tumor .Although P300/CBP is usually regarded as a tumor sup-pressor factor ,is plays different roles in different tumors ,This review mainly introduces the relationship of P 300/CBP with some solid tumor disease genes ,related transcription factors and their signaling pathways .%P300/CBP是组蛋白乙酰转移酶（ HAT）中重要的大分子蛋白之一，P300/CBP具有高度的同源性，虽然由不同的基因编码，但因其有相近的氨基酸排序和功能，而且又属于同一类的蛋白质，所以经常把它们写为P300/CBP。 P300/CBP参与了很多种转录因子的激活，它本身也存在着乙酰转移酶活性，能够乙酰化4种核心组蛋白和多种转录因子。越来越多的研究证实P300/CBP的变异与人类多种疾病，糖尿病，炎症、心脏病，特别是肿瘤的发病相关，P300/CBP在肿瘤中也与一些通路有相关性，而这些通路在肿瘤中扮演着不同的角色。 P300/CBP虽然通常被看做是肿瘤抑制因子，但是在不同的肿瘤中P300/CBP也起着不同的作用，本文主要介绍了P300/CBP与一些实体肿瘤发病相关的基因之间的作用以及有关的转录因子和相关的转导通路。