转铁蛋白-转铁蛋白受体抗肿瘤作用研究进展

摘要

The transferrrin(Tf)and the transferrin receptor(TfR)are effective anti tumor agents which exist widely in human body .The Tf takes an important role in iron metabolism ,while the TfR disturbs iron metab-olism and controls the iron absorbing .The compound of Tf and TfR can induce tumor cells apoptosis .Therefore , the combination of Tf and TfR can inhibit tumor growth efficiently .In addition,it is also good for anti tumor indi-rectly by taking Tf/TfR as target and using artemisinin .This article will review and summarize the anti tumor effect of transferrin and transferrin receptor .%转铁蛋白（ Transferrin，Tf）与转铁蛋白受体（ Transferrin receptor ，TfR）抗肿瘤作用显著，它们广泛存在于人体中。 Tf参与铁的代谢，TfR干扰铁的代谢，控制铁的吸收，与转铁蛋白组成复合物诱导肿瘤细胞凋亡。 Tf与TfR的结合，共同通过维持铁代谢，调节细胞生长与代谢和肿瘤细胞的代谢。本文就转铁蛋白－转铁蛋白受体在抗肿瘤方面的作用进行综述。